TWiV 995: Viral origin stories

TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid. Click arrow to play Download TWiV 995 (74 MB .mp3, 123 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server • More evidence for SARS-CoV-2 spillover (Zenodo) •Polio cases linked to nOPV2 (Science; GPEI statement) •nOPV2 on TWiV 756 •Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe) •Stability of nOPV2 in children (npj Vaccines) •2A changes compensate for 5′-UTR disruptions (Virology) •HBV shifts from naked to enveloped (Nat Comm) •Letters read on TWiV 995 •Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath Angela – The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons Brianne – Science Museums Take Stock of 1.1 Billion Objects from Around the World Vincent – Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York Listener Picks Gary – Tony Fauci on PBS Stefanie – What Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv